| Article |
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| Article name |
The Role of Experimental Lactat-Acidosis in the Development of Structure Violations of Spleen |
| Authors |
Alfonsova Y.V. Candidate of Science (Medicine), elena-alfonsova@yandex.ruBochkarnikova .V. Candidate of Science (Medicine), associate professor, head of the Department of Medical and Biological bases of Physical Education and Sports, Bochkarnikova@zabspu.ru |
| Bibliographic description |
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| Section |
Scientific Research |
| UDK |
УДК 616.15 |
| DOI |
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| Article type |
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| Annotation |
The article containts data on the influence of metabolic acidosis on structure organization
of spleen. They made metabolic acidosis by intravenous injection 3 % solution of
lactate into the femoral vein to cats and get various improvements pH from 7,25 to 6,5. In
spleen unspecific changes arise, such as: edema and destruction of capsule and capsular
septa, argyrophil frame, delymphatisation of parenchyma, all these changes depend on
depth and duration of acidosis. Basing on morphological researches in vessels of microcirculatory
channel with pH 7,2, the sledges of erythrocytes and aggregates of thrombocytes
are formed, degranulation of mast cells take place, deplacement pH to 7,0–6,8 leads to
the formation of intravascular thrombs, violation the integrity of endothelial cells in the
microcirculatory channel. We think that similar changes lead to the development of immunodeficient
state in acidosis.
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| Key words |
acidosis, lactate, morphology, spleen, fibrosis, immunodeficient state. |
| Article information |
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| References |
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| Full article | The Role of Experimental Lactat-Acidosis in the Development of Structure Violations of Spleen |
