| Article |
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| Article name |
The Role of Experimental Lactat-aAcidosis in the Development of DIC-Syndrome and Disorders of Structural Organization of Myocardium |
| Authors |
Zaborina L.G. Candidate of Psychology, Associate Professor, zaborinalarisa@yandex.ruAlfonsova Y.V. Candidate of Science (Medicine), elena-alfonsova@yandex.ru |
| Bibliographic description |
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| Section |
Scientific Research |
| UDK |
УДК 616.15 |
| DOI |
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| Article type |
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| Annotation |
The article containts data on the regularities of the development of DIC-syndrome
and also disorders of structural organization of myocardium. Metabolic acidosis, caused in
the experiment on 42 animals (cats) by intravenous injection 3 % a lactate acid in up to a
pH level 7,2–6,5 and duration up to 15–180 min. Acidosis causes the development of DICsyndrome.
According to the data of electronic microscopy characteristics mitochondrial
dysfunction is revealed. At the pH 7,1 and the duration of more than 60–100 minutes
the discovered changes in cardiac hystiocytes should be interpreted as “irreversible”,
“focal injuries” of myocardium. The pH-displacement to 7,0 leads to the dystrophy
and necrobiosis of cardiac hystiocytes. Further the pH-displacement to 6,9 leads to the
development of acute myocardial infarction in the phase of necrosis.
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| Key words |
acidosis, lactate, DIC-syndrome, morphology, myocardium. |
| Article information |
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| References |
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| Full article | The Role of Experimental Lactat-aAcidosis in the Development of DIC-Syndrome and Disorders of Structural Organization of Myocardium |
