| Article |
|---|
| Article name |
The Role of Metabolic Acidosis in the Development of Hemostasis System Disorders and the Occurrence of DIC-syndrome in Critical Condition Patients |
| Authors |
Zabrodina L.A. postgraduate, Department of Medical and Biological bases of Physical Education and Sports, Alfonsova@zabspu.ruAlfonsova Y.V. Candidate of Science (Medicine), elena-alfonsova@yandex.ru |
| Bibliographic description |
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| Section |
Human and Animal Physiology |
| UDK |
616.152.112 |
| DOI |
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| Article type |
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| Annotation |
A retrospective analysis of 30 metabolic acidosis surgical patients’ cases was carried
out in order to study and identify the significance of disturbances of acid-base balance
(ABB) in the development of disseminated intravascular coagulation (DIC). A correlation
analysis revealed statistically significant inverse correlations between the International
Normalized Ratio (INR) and the concentration of standard bicarbonate (SB), base excesses
(BE), total СО2, between prothrombin time (PT) and concentration of bicarbonates
(НСО3
-); activated partial thromboplastin time (aPTT) and total CO2. Against the background
of correction of the acid-base balance the study defined direct significant correlations
among the concentration of fibrinogen and blood pH, pressure of oxygen (pO2), SB,
ВE, tCO2, НСО3
-, between aPTT and SB. Thus, metabolic disorders of patients in critical
conditions are a risk factor in the development of DIC-syndrome.
|
| Key words |
acid-base balance (ABB), metabolic acidosis, critical condition, hemostasis,
DIC-syndrome. |
| Article information |
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| References |
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| Full article | The Role of Metabolic Acidosis in the Development of Hemostasis System Disorders and the Occurrence of DIC-syndrome in Critical Condition Patients |
