| Article |
|---|
| Article name |
The Effect of Nootropics on the Acid-Base Balance in Rats with Oxygen Deficiency |
| Authors |
Stasyuk O.N. graduate student, olga-stasuk4@rambler.ru |
| Bibliographic description |
|
| Section |
Human and Animal Physiology |
| UDK |
616 |
| DOI |
|
| Article type |
|
| Annotation |
The article deals with the effect of nootropics on the rats under hypoxia. The study
is based on germovolume hypoxia as a model of hypoxia which considerably changes the
acid-base balance of blood. The indices of pH, pCO2, and pO2 decrease, i. e. the author
registers respiratory acidosis. Piracetam in the dose with antihypoxic effect (50mg/kg)
has a protective effect comparable to the action of sodium hydroxybutyrate, which is
considered an etalon of antihypoxic effect. The substance of nootropic type, meclofenoxate
(100 mg/kg), with no antihypoxic effect, also has a protective effect on rats in the state
of hypoxia. All studied substances had a protective effect on the acid-base balance during
hypoxia, set on this model.
|
| Key words |
hypoxia, acidosis, alkalosis, nootropics, piracetam, natrium oxybutyrate,
meclofenoxate. |
| Article information |
|
| References |
|
| Full article | The Effect of Nootropics on the Acid-Base Balance in Rats with Oxygen Deficiency |
