| Authors |
Avseenko N.D. Doctor of Medicine, Associate Professor, ndavseenko@rambler.ruAlfonsova Y.V. Candidate of Science (Medicine), elena-alfonsova@yandex.ruZabrodina L.A. postgraduate, Department of Medical and Biological bases of Physical Education and Sports, Alfonsova@zabspu.ruStasyuk O.N. graduate student, olga-stasuk4@rambler.ru |
| Annotation |
Retrospective analysis of 28 medical patients’ histories from endocrinology department of
the Chita regional clinical hospital from 2009 to 2011 was performed. Acid-base balance and water-
electrolytic balance blood pH parameters, electrolytes and hemostasis volume were estimated. Against the background of progressive metabolic acidosis essential changes of hemostasis were
found out in the form of increase of D-dimers concentration, resolution of platelet number, prolongation
activated partial thromboplastin time (APTT) and international normalized ratio (INR).
There were statistically significant inverse correlations between INR and concentration of standard
bicarbonates (SB), buffer excesses (BE), concentration of hydrogen carbonates (НСО3-), carbon
dioxide СО2. Also there were inverse correlations between prothrombin time and concentration of
hydrogen carbonates (НСО3-), standard bicarbonates (SB), buffer excesses (BE), carbon dioxide
СО2. It testifies to the development of hypercoagulation state. According to the data presented in the
electrocardiography (ECG) sinus tachycardia, ventricular fibrillation, paroxysmal supraventricular
arrhythmia, the increase of creatinine and urea in blood are observed. All patients having metabolic
acidosis have symptoms of development of multiple organ failure on the background of progressing
disseminated intravascular coagulation (DIC).
|
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