Article
Article name The Role of Metabolic Acidosis in the Shifts Development in Hemostasis and Multiple Organ Failure in Patients Having Diabetes Mellitus
Authors Avseenko N.D. Doctor of Medicine, Associate Professor, ndavseenko@rambler.ru
Alfonsova Y.V. Candidate of Science (Medicine), elena-alfonsova@yandex.ru
Zabrodina L.A. postgraduate, Department of Medical and Biological bases of Physical Education and Sports, Alfonsova@zabspu.ru
Stasyuk O.N. graduate student, olga-stasuk4@rambler.ru
Bibliographic description
Section Human and Animal Physiology
UDK 616.152.11
DOI
Article type
Annotation Retrospective analysis of 28 medical patients’ histories from endocrinology department of the Chita regional clinical hospital from 2009 to 2011 was performed. Acid-base balance and water- electrolytic balance blood pH parameters, electrolytes and hemostasis volume were estimated. Against the background of progressive metabolic acidosis essential changes of hemostasis were found out in the form of increase of D-dimers concentration, resolution of platelet number, prolongation activated partial thromboplastin time (APTT) and international normalized ratio (INR). There were statistically significant inverse correlations between INR and concentration of standard bicarbonates (SB), buffer excesses (BE), concentration of hydrogen carbonates (НСО3-), carbon dioxide СО2. Also there were inverse correlations between prothrombin time and concentration of hydrogen carbonates (НСО3-), standard bicarbonates (SB), buffer excesses (BE), carbon dioxide СО2. It testifies to the development of hypercoagulation state. According to the data presented in the electrocardiography (ECG) sinus tachycardia, ventricular fibrillation, paroxysmal supraventricular arrhythmia, the increase of creatinine and urea in blood are observed. All patients having metabolic acidosis have symptoms of development of multiple organ failure on the background of progressing disseminated intravascular coagulation (DIC).
Key words acidosis, disseminated intravascular coagulation (DIC), multiple organ failure, diabetes mellitus.
Article information
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Full articleThe Role of Metabolic Acidosis in the Shifts Development in Hemostasis and Multiple Organ Failure in Patients Having Diabetes Mellitus